Team SyBER, UMR MICALIS

Synthetic Biology aims to engineer novel biological functions and systems for applications in health, biomanufacturing, and the environment. While researchers have successfully synthesized compounds in microorganisms, challenges remain due to limited well-characterized genetic elements, unwanted interactions, and the need to explore novel biological functions.

To address these challenges, our strategy involves multidisciplinary approaches, including cutting-edge genome engineering methodologies, adaptive laboratory evolution, in vivo and cell free-based high-throughput phenotyping, and modeling within three complementary research axes:

Axis 1. Decoding gene expression for precise control of synthetic circuitry;

Axis 2. Synthetic bacteria and consortia designed for the identification and characterization of fundamental cellular functions; and,

Axis 3. Synthetic devices engineered to establish orthogonality and conceive novel functions.