We investigate the influence of crystallographic twins on the elastoplastic response of γ-TiAl intermetallics via full-field FFT-based computations. We first introduce a hierarchical stochastic model, which is used to simulate synthetic polycrystalline microstructures containing twin grains with certain morphologies, and apply it to generate representative volume elements. Second, we develop a Fourier-based method with regularization for solving the effective and local mechanical response of polycrystalline media using the Méric-Cailletaud crystal plasticity constitutive law. Numerical results show that, across configurations of twinning, the corresponding average effective response is similar. Although differences were quantified, the effect of twins on the yield stress is negligible in practice (less than 1%).