Cognitive change in breast cancer patients up to 2 years after diagnosis - Centre Henri Becquerel
Journal Articles JNCI: Journal of the National Cancer Institute Year : 2022

Cognitive change in breast cancer patients up to 2 years after diagnosis

Christelle Lévy
Laure Médeau
  • Function : Author
Florence Lerebours
Ophélie Querel
  • Function : Author
Sibille Everhard
  • Function : Author
Fabrice André
  • Function : Author
Sarah Dauchy
  • Function : Author
Florence Joly
  • Function : Author

Abstract

BACKGROUND: Using the large nationwide CANTO cohort, we assessed cognitive functioning change after cancer treatments in a subgroup of breast cancer patients. METHODS: We included patients with newly diagnosed invasive stage I-III breast cancer enrolled in the CANTO sub-study focused on cognitive evaluation and healthy control women matched for age and education. Episodic and working memory, executive functions, processing speed, attention, self-report cognitive difficulties (SRCD), fatigue, anxiety/depression were assessed with neuropsychological tests and self-report questionnaires, before treatment (baseline), about 1 (year-1) and 2 years (year-2) after diagnosis. We used linear mixed models to study changes in cognition and tested the effect of adjuvant chemotherapy. RESULTS: We studied 276 localized breast cancer patients (62% chemotherapy (CT+)) compared to 135 healthy controls. After adjustment, patients had lower baseline working memory, processing speed and attention scores than healthy controls (p ≤ 0.001), and the difference remained significant over follow-up for working memory and processing speed. Executive function scores were similar between groups at baseline but decreased at year-1 among patients compared to healthy controls (p for change = 0.006). This decrease in CT+ patients was significant when compared to healthy controls scores (p for change < 0.001). After adjustment, SRCD were similar between breast cancer patients and healthy controls at baseline but increased in patients after treatment at year-1 (p for change = 0.002). CONCLUSIONS: Cognitive difficulties are an important concern in breast cancer patients, starting at diagnosis. Cancer treatments induce executive function decline and SRCD, which decrease over follow-up.
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Dates and versions

hal-03992251 , version 1 (04-06-2024)

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Marie Lange, Sophie Lefevre Arbogast, Isabelle Hardy-Léger, Olivier Rigal, Johan Le Fel, et al.. Cognitive change in breast cancer patients up to 2 years after diagnosis. JNCI: Journal of the National Cancer Institute, 2022, 115 (3), pp.322-331. ⟨10.1093/jnci/djac240⟩. ⟨hal-03992251⟩
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